A complete list of Dr. Rothstein’s publications can be found in PubMed
Selected Publications
Workman MJ, et al. Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects. Neuron. 2023; 111(8):1191-1204.e5. doi: 10.1016/j.neuron.2023.01.010.
Baxi EG, et al. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nat Neurosci. 2022; 25(2):226-237. doi: 10.1038/s41593-021-01006-0.
Coyne AN, et al. Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Sci Transl. Med. 2021; 13(604): eabe1923. doi: 10.1126/scitranslmed.abe1923.
Zaepfel BL, et al. UPF1 reduces C9orf72 HRE-induced neurotoxicity in the absence of nonsense-mediated decay dysfunction. Cell Rep. 2021; 34(13): 108925. doi: 10.1016/j.celrep.2021.108925.
Coyne AN, et al. G4C2 repeat RNA initiates a POM121-mediated reduction in specific Nucleoporins in C9orf72 ALS/FTD. Neuron. 2020; 107(6): 1124-1140.e11. doi: 10.1016/j.neuron.2020.06.027.
Hayes LR, Duan L, Bowen K, Kalab P, Rothstein JD. C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import. Elife. 2020; 2: 9:e51685. doi: 10.7554/eLife.51685.
Miller SJ, et al. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. 2019; 22(5): 741-752. doi: 10.1038/s41593-019-0366-7
Zhang K, et al. Stress granule assembly disrupts nucleocytoplasmic transport. Cell. 2018; 173(4): 958-971.e17. doi: 10.1016/j.cell.2018.03.025.
Grima JC, et al. Mutant Huntingtin disrupts the nuclear pore complex. Neuron. 2017; 94(1): 93-107.e6. doi: 10.1016/j.neuron.2017.03.023.
Miller SJ, Zhang PW, Glatzer J, Rothstein JD. Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model. J Neurogenet. 2017; 31(1-2): 37-48. doi: 10.1080/01677063.2016.1260128.
