Brett Morrison, M.D., Ph.D.
Dr. Brett Morrison specializes in neuromuscular disorders in adults including amyotrophic lateral sclerosis, motor neuropathies, myasthenia gravis and muscle diseases including myopathy and muscular dystrophy.
Dr. Morrisons research interests include investigations into the basic mechanisms of acute denervation and the development of treatments for chronic denervating diseases such amyotrophic lateral sclerosis or motor neuropathies. Current research focuses on treatments designed to reduce muscle loss and atrophy, and thus preserve function, following denervation..
All Publications of Brett Morrison in PubMed
Recent Publications:
Lee, Y.*, Morrison, B.M.*, Li, Y., Lengacher, S., Farah, M.H., Hoffman, P.N., Liu, Y., Tsingalia, A., Jin, L., Zhang, P-W., Pellerin, L., Magistretti, P.J., Rothstein, J.D. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature 2012; 487 (7408): 443-448. *Co-First Authors
Morrison, B. M.,* Tsingalia, A., Vidensky, S., Lee, Y., Jin, L., Farah, M. H., Lengacher, S., Magistretti, P. J., Pellerin, L. & Rothstein, J. D. Deficiency in monocarboxylate transporter 1 (MCT1) in mice delays regeneration of peripheral nerves following sciatic nerve crush. Exp. Neurology 2015: 263: 325-338.
Jha, M.K., Lee, Y., Russell, K.A., Yang, F., Dastgheyb, R.M., Deme, P. Ament, X.H., Chen, W., Liu, Y., Guan, Y., Polydefkis, M.J., Hoke, A., Haughey, N.J., Rothstein, J.D., Morrison, B. M.* Monocarboxylate transporter 1 in Schwann cells contributes to the maintenance of sensory nerve myelination during aging. Glia 2020; 68 (1): 161-77.
Mordes, D.A*, Morrison, B.M.*, Ament, X.H., Cantrell, C., Mok, J., Eggan, P., Xue, C., Wang, J-Y., Eggan, K., Rothstein, J.D. Absence of survival and motor deficits in 500 repeat C9ORF72 BAC mice. Neuron 2020; 108: 775-783. *Co-First Authors
Jha, M.K., Ament, X.H., Yang, F., Liu, Y., Polydefkis, M.J., Pellerin, L., Morrison, B.M. Reducing monocarboxylate transporter 1 MCT1 worsens experimental diabetic peripheral neuropathy. Exp. Neurol. 2020; 330 113415.
Morrison BM. Surprising New Players in Glia-Neuron Crosstalk: Role in CNS Regeneration. Cell Metab. 2020 Nov 3;32(5):695-696. doi: 10.1016/j.cmet.2020.10.009. PMID: 33147480.
Philips, T., Mironova, T.A., Jouroukhin, Y., Chew, J., Vidensky, S., Farah, M., Pletnikov, M.V., Bergles, D.E., Morrison, B.M.*,Rothstein J.D.* MCT1 deletion in oligodendrocyte lineage cells causes late-onset hypomyelination and axonal degeneration. Cell Reports 2021; 34: 108610. *Co-Corresponding Authors
Jha MK, Passero JV, Rawat A, Ament XH, Yang F, Vidensky S, Collins SL, Horton MR, Hoke A, Rutter GA, Latremoliere A, Rothstein JD, Morrison BM. Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration after injury in mice. J Clin Invest. 2021 Nov 1;131(21):e141964.
Rawat A, Morrison BM. Metabolic Transporters in the Peripheral Nerve-What, Where, and Why? Neurotherapeutics. 2021 Oct;18(4):2185-2199.