Selected Publications:

Ruan, L., McNamara, J., Zhang, X., Chang, A., Zhu, J., Dong, Y., Sun G., Peterson, A., Na, C.H., Li, R. (2020) Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix. Science Advances. Vol. 6, no. 32, eabc7288.

Ruan, L., Wang, Y., Zhang, X., Tomaszewski A., McNamara J., Li, R. (2020) Mitochondria‐Associated Proteostasis. Annual Review of Biophysics. 2020 49:1, 41-67.

Ruan, L., Zhang, X., Li, R. (2018). Recent insights into the cellular and molecular determinants of aging. Journal of Cell Science 2018 131: jcs210831.

Ruan, L., Zhou, C., Jin, E., Kucharavy, A., Zhang, Y., Wen, Z., Florens, L., and Li, R. (2017). Cytosolic proteostasis through importing of misfolded proteins into mitochondria. Nature 543, 443-446.

Perry, J.M., Tao, F., Roy, A., Lin, T., He, X.C., Chen, S., Lu, X., Nemechek, J., Ruan, L., Yu, X., Dukes, D., Moran, A., Pace, J., Schroeder, K., Zhao, M., Venkatraman, A., Qian, P., Li, Z., Hembree, M., Paulson, A., He, Z., Xu, D., Tran, T.H., Deshmukh, P., Nguyen, C.T., Kasi, R.M., Ryan, R., Broward, M., Ding, S., Guest, E., August, K., Gamis, A.S., Godwin, A., Sittampalam, G.S., Weir, S.J., Li, L. Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells. Nature Cell Biology. 2020 Jun;22(6):689-700. doi: 10.1038/s41556-020-0507-y. Epub 2020 Apr 20.

Zhu, L., Xu, M., Yang, M., Yang, Y., Li, Y., Deng, J., Ruan, L., Liu, J., Du, S., Liu, X., Feng, W., Fushimi, K., Bigio, EH, Mesulam, M., Wang, C., Wu, JY. (2014). An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel beta-structure and induces TDP-43 redistribution. Human molecular genetics 23, 6863- 6877.